Virtual issue: Recent advances in pediatric headache: Bridging the data gap - Peeref (2024)

Review Oncology

Recent Advances in Pediatric Cancer Research

Troy A. McEachron, Lee J. Helman

Summary: In recent years, there has been a significant shift in the field of pediatric cancer research, focusing on genetic and epigenetic drivers of disease, cellular origins of different pediatric cancers, disease models, the tumor microenvironment, and cellular immunotherapies.

Review Clinical Neurology

Recent Advances in Pediatric Medulloblastoma

Kasey Jackson, Roger J. Packer

Summary: This review provides an overview of recent advances in the understanding and management of pediatric medulloblastoma, including etiology, biology, radiology, and treatment.

Review Clinical Neurology

Recent Advances in Neuropsychological Outcomes and Intervention in Pediatric Stroke

Lauren S. Krivitzky, Robyn Westmacott, Richard Boada, Leigh Sepeta, Lauren Reppert, Christine Mrakotsky

Summary: Significant progress has been made in the treatment of acute and chronic medical consequences of stroke in childhood. This article provides a review of the current literature on neuropsychological outcomes in pediatric stroke and discusses recent developments in functional neuroimaging and rehabilitation intervention models. Future directions for clinical practice and research in pediatric stroke are also discussed.

Editorial Material Computer Science, Artificial Intelligence

Recent advances in domain-driven data mining

Chuanren Liu, Ehsan Fakharizadi, Tong Xu, Philip S. Yu

Summary: This article introduces the importance and application value of domain-driven data mining in real-world applications, summarizes the selected papers in this special issue, discusses relevant industrial trends, and records the keynote talks presented at the workshop. The article also points out that although significant contributions have been made in domain-driven data mining, there are still new problems and challenges that require further research.

Review Immunology

Immunotherapy for Pediatric Acute Lymphoblastic Leukemia: Recent Advances and Future Perspectives

Meng Lv, Yan Liu, Wei Liu, Yabing Xing, Shengnan Zhang

Summary: Pediatric acute lymphoblastic leukemia (ALL) is a common subtype of childhood leukemia characterized by abnormal proliferation of immature lymphoid cells in the bone marrow. Immunotherapy, including bispecific T-cell engagers and chimeric antigen receptor T cells, has shown promise in improving cure rates and quality of life for pediatric ALL patients, but challenges remain.

Article Computer Science, Information Systems

Recent Advances in Data Engineering for Networking

Engin Zeydan, Josep Mangues-Bafalluy

Summary: This tutorial paper discusses recent advancements in data engineering, specifically in network management and orchestration. The authors analyze standardization efforts and platform development activities related to data engineering-driven network design. They find that there is still a significant gap in applying these developments to the telecommunication domain. The paper concludes by discussing these gaps and research challenges, and proposing recommendations for early adoption of these technologies in telecommunications infrastructure and platforms.

Review Allergy

Pediatric problematic severe asthma: Recent advances in management

Elizabeth Scotney, Saskia Burchett, Thomas Goddard, Sejal Saglani

Summary: Problematic severe asthma in children presents a significant challenge in management, with clinical phenotypes guiding treatment but many unknown areas remaining. Novel therapeutic strategies are being increasingly utilized for difficult-to-treat asthma, but pediatric data is still limited.

Review Mathematics

Recent Advances on Penalized Regression Models for Biological Data

Pei Wang, Shunjie Chen, Sijia Yang

Summary: This review focuses on recent advances in penalized regression models, including linear and logistic regression models, and their applications in biological data. The pros and cons of different models in terms of response prediction, sample classification, network construction, and feature selection are also discussed. The performance of different models in a real-world RNA-seq dataset for breast cancer is explored, and future directions are suggested.

Review Computer Science, Hardware & Architecture

The Lean Data Scientist: Recent Advances toward Overcoming the Data Bottleneck

Chen Shani, Jonathan Zarecki, Dafna Shahaf

Summary: A classification of methods for obtaining quality datasets improves the value of existing resources.

Review Pharmacology & Pharmacy

Orodispersible tablets for pediatric drug delivery: current challenges and recent advances

Raphael Wiedey, Marcel Kokott, Jorg Breitkreutz

Summary: This review highlights the importance of child appropriate dosage forms in successful pediatric drug therapy, focusing on recent developments in Orodispersible tablets (ODTs) and mini-tablets (ODMTs). Despite the potential of OD(M)Ts, there is a lack of direct acceptance studies in children, resulting in limited knowledge and reluctance in therapeutic use and research studies. However, existing evidence suggests no limitations in the use of ODTs in pediatric patients.

Review Multidisciplinary Sciences

Recent advances in urban system science: Models and data

Elsa Arcaute, Jose J. Ramasco

Summary: Cities are characterized by a dense population and high interactions among individuals from diverse backgrounds, originating parallel to the Neolithic revolution millennia ago. Their advantages in terms of economy, innovation, social and cultural progress have made them a major landmark in recent human history. From a scientific perspective, studying urban systems involves various aspects such as demography, mobility, economic output, land use, urban planning, housing accessibility, energy and water consumption, waste processing, health, education, and integration of minorities.

Review Respiratory System

Pediatric bronchoscopy: recent advances and clinical challenges

P. Goussard, P. Pohunek, E. Eber, F. Midulla, G. Di Mattia, M. Merven, J. T. Janson

Summary: Pediatric bronchoscopy has seen advancements in technology and widespread clinical application in recent decades, with a variety of interventional treatment options such as balloon dilatation and airway stents. Additionally, the impact of the COVID-19 pandemic has led to safer bronchoscopy practices in clinical settings.

Review Chemistry, Physical

Recent advances in the data-driven development of emerging electrocatalysts

Keda Ding, Tong Yang, Man Tai Leung, Ke Yang, Hao Cheng, Minggang Zeng, Bing Li, Ming Yang

Summary: This article provides an overview of data-driven strategies in the design of high-performance electrocatalysts, including high throughput experiments, high-throughput calculations, and machine learning. By integrating these methods, the development of electrocatalysts can be accelerated, promoting the advancement of green energy technologies and addressing the challenges posed by global climate change.

Article Social Sciences, Mathematical Methods

Recent Advances in Data Integration

Joseph W. Sakshaug, Rebecca C. Steorts

Summary: The availability of various data sources, including survey and non-survey data, has significantly increased in the past decade. However, integrating multiple data sources poses statistical, methodological, computational, and ethical challenges. This special issue addresses these challenges by showcasing recent innovations and applications in data integration and related topics.

Article Green & Sustainable Science & Technology

Recent advances on industrial data-driven energy savings: Digital twins and infrastructures

Sin Yong Teng, Michal Tous, Wei Dong Leong, Bing Shen How, Hon Loong Lam, Vitezslav Masa

Summary: Data-driven models for industrial energy savings rely heavily on sensor data, experimentation data, and knowledge-based data rather than ensuring the quality of industrial data. The true challenge within Industry 4.0 lies in data communication and infrastructure issues rather than the development of modeling techniques. With advancements in enabling technologies such as 5G, IoT standardization, AI, and blockchain 3.0, the industry is transitioning towards a digital twin-based approach.

Article Anesthesiology

Systematic evaluation of commercially available pain management apps examining behavior change techniques

Kaitlyn L. Gamwell, Sophie R. Kollin, Robert C. Gibler, Helen Bedree, Keely H. Bieniak, Anjana Jagpal, Susan T. Tran, Kevin A. Hommel, Rachelle R. Ramsey

Summary: Mobile health (mHealth) apps have the potential to enhance pain management, but the extent to which these apps use evidence-based behavior change techniques remains largely unknown. This study evaluated the quality and evidence-based BCTs of commercially available pain management apps, finding that some apps utilize evidence-based strategies.

Review Clinical Neurology

Psychological Interventions for Pediatric Headache Disorders: A 2021 Update on Research Progress and Needs

Kaelynn E. Knestrick, Robert C. Gibler, Brooke L. Reidy, Scott W. Powers

Summary: This review summarizes recent findings on psychological interventions for pediatric headache disorders and discusses the potential for optimization and expanding access to these interventions. Cognitive Behavioral Therapy (CBT) has shown effectiveness in reducing headache days, but its impact on disability associated with migraine is mixed. Complementary or alternative interventions, such as Acceptance and Commitment Therapy (ACT) and mindfulness-based approaches, could be utilized to enhance CBT. Tailoring CBT to patients with more impairing or complex clinical presentations, such as continuous headache, is crucial. The use of eHealth and novel study designs shows promise in reaching and disseminating psychological interventions. Further research is needed to better understand the efficacy and mechanisms of CBT, as well as to explore other promising psychological treatments.

Editorial Material Clinical Neurology

Advancing our commitment to our peer reviewers

Rashmi B. Halker Singh, Sarah M. Bobker, Jason L. Roberts, Larry Charleston, Matthew S. Robbins, Amynah Pradhan, Till Sprenger, Patricia Pozo-Rosich, Serena L. Orr, Scott W. Powers, Timothy T. Houle, Dana P. Turner, Amy A. Gelfand

Article Clinical Neurology

Adverse childhood experiences and onset of migraine in Canadian adolescents: A cohort study

Nicole G. Hammond, Ian Colman, Serena L. Orr

Summary: Adverse childhood experiences (ACEs) may increase the risk of migraine onset in adolescence, and this association is not explained by symptoms of depression and anxiety in late childhood.

Article Psychology, Developmental

Establishing the Content Validity of a Modified Bank of School Anxiety Inventory Items for Use Among Adolescents With Chronic Pain

Robert C. Gibler, Elana Abelson, Sara E. Williams, Anne M. Lynch-Jordan, Susmita Kashikar-Zuck, Kristen E. Jastrowski Mano

Summary: This study aimed to refine the existing measure of school anxiety, the School Anxiety Inventory, Short Version (SAI-SV), for youth with chronic pain. By obtaining qualitative data and generating new item content, the researchers developed the School Anxiety Inventory for Chronic Pain. The updated measure was found to be highly relevant and further research is needed for psychometric evaluation and finalization of items.

Editorial Material Clinical Neurology

The elephant in the room: How the underfunding of headache research stunts the field

Serena L. Orr, Robert E. Shapiro

Review Clinical Neurology

Digital headache self-management interventions for patients with a primary headache disorder: A systematic review of randomized controlled trials

Amy E. Noser, Robert C. Gibler, Rachelle R. Ramsey, Rebecca E. Wells, Elizabeth K. Seng, Kevin A. Hommel

Summary: This article systematically reviews the efficacy of digital headache management interventions for patients with a primary headache disorder. The findings suggest that digital interventions can significantly improve headache outcomes. Most interventions were delivered through interactive websites and showed promising results. However, the studies mainly focused on hom*ogenous patient populations, emphasizing the need for further large-scale randomized controlled trials and exploration of other digital tools. Studies with more diverse samples are needed to promote health equity in digital headache interventions.

Editorial Material Clinical Neurology

Status Migrainosus One of the Most Poorly Understood but Important Complications of Migraine

Serena L. Orr

Article Clinical Neurology

Impact of preventive pill-based treatment on migraine days: A secondary outcome study of the Childhood and Adolescent Migraine Prevention (CHAMP) trial and a comparison of self-report to nosology-derived assessments

Robert C. Gibler, James L. Peugh, Christopher S. Coffey, Leigh Ann Chamberlin, Dixie Ecklund, Elizabeth Klingner, Jon Yankey, Leslie L. Korbee, Marielle Kabbouche, Joanne Kacperski, Linda L. Porter, Brooke L. Reidy, Andrew D. Hershey, Scott W. Powers

Summary: This study aims to examine group differences in self-reported migraine days among youth who completed the CHAMP trial and explore the relationship between self-reported and nosology-derived migraine days. The results showed no significant differences in self-reported migraine days between treatment groups. There was a strong association between self-reported and nosology-derived migraine days.

Article Clinical Neurology

Impact of monthly headache days on migraine-related quality of life: Results from the Chronic Migraine Epidemiology and Outcomes (CaMEO) study

Richard B. Lipton, Patricia Pozo-Rosich, Serena L. Orr, Michael L. Reed, Kristina M. Fanning, Brett Dabruzzo, Dawn C. Buse

Summary: This study aimed to explore the direct impact of monthly headache days (MHDs) on the health-related quality of life (HRQoL) in people with migraine, as well as the potential mediating effects of anxiety, depression, and allodynia.

Review Clinical Neurology

Variation in Endpoints in FDA Medication Approvals

Leigh K. Sharpless, Aaron S. Kesselheim, Serena L. Orr, Jonathan Darrow

Summary: This study assessed the characteristics and variation of endpoints used in trials supporting FDA approval of medications for migraine treatment. The findings revealed inconsistent endpoint selection within the same indication, mechanistic class, and route of administration, making it difficult to directly compare these medications. Inconsistent definitions for episodic and chronic migraine were also observed.

Review Pediatrics

Management of Chronic Migraine in Children and Adolescents: Where are We in 2022?

Robert C. Gibler, Kaelynn E. Knestrick, Brooke L. Reidy, Daniel N. Lax, Scott W. Powers

Summary: This review provides a comprehensive overview of the management of chronic migraine in children and adolescents, including both acute and preventive treatments. It highlights the importance of a holistic, multidisciplinary, and biopsychosocial approach to treatment.

Article Genetics & Heredity

A Pilot Study Investigating the Role of Gender in the Intergenerational Relationships between Gene Expression, Chronic Pain, and Adverse Childhood Experiences in a Clinical Sample of Youth with Chronic Pain

Jennaya Christensen, Jaimie K. Beveridge, Melinda Wang, Serena L. Orr, Melanie Noel, Richelle Mychasiuk

Summary: The study found that parental trauma increases the risk of children developing chronic pain issues, potentially mediated by epigenetic mechanisms. Gender and the nature of ACE (maltreatment vs. household dysfunction) may be associated with specific epigenetic changes.